Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321

نویسندگان

  • Yongxiang Song
  • Jiajian Wang
  • Hongbo Huang
  • Lin Ma
  • Jun Wang
  • Yucheng Gu
  • Lan Liu
  • Yongcheng Lin
چکیده

Three new eremophilane sesquiterpenes (1-3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC₅₀ value is 6.54 μM.

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عنوان ژورنال:

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2012